Hell architect igg6/7/2023 ![]() Received: SeptemAccepted: DecemPublished: February 4, 2022Ĭopyright: © 2022 Jugwanth et al. PLoS ONE 17(2):Įditor: Han-Chung Wu, Academia Sinica, TAIWAN ![]() (2022) Performance of the Abbott SARS-CoV-2 IgG serological assay in South African 2 patients. Based on the current findings testing of IgG after 14 days is recommended in South Africa and supports other studies performed around the world.Ĭitation: Jugwanth S, Gededzha MP, Mampeule N, Zwane N, David A, Burgers WA, et al. Specificity for Abbott Alinity assays was 91.7% higher than Abbott Architect 88.1%. The Abbott assay was also compared to in house ELISA assay, with sensitivity for the Architect and Alinity assays of 94.7% and 92.5%, respectively. Specificity for Architect and Alinity assays was 95% and 90.3%, respectively. When compared to RT-qPCR, the sensitivity of Architect and Alinity SARS-CoV2 assays was 69.5% and 64.8%, respectively. ![]() A total of number of 530 participants was tested, 87% were symptomatic with infection and 13% were asymptomatic. In-house ELISA was incorporated into the study as a confirmatory serology test. The Architect-i and Alinity-i systems were analyzers that were used to perform the SARS-CoV-2 IgG assay. Positive patients (n = 391) and negative controls (n = 139) were included. This study undertook to validate and evaluate performance criteria of the Abbott assay and to establish whether this assay would show clinical utility in our population. The Abbott SARS-CoV2 assay detects IgG antibodies against the Nucleocapsid (N) protein of the SARS-CoV2 virus. A key component of South Africa’s response to SARSCoV2 was the rapid scale-up of diagnostic testing. South Africa, despite strict and early lockdown has the highest infection rate in Africa. This virus was named SARS-CoV2 and the clinical syndrome was named coronavirus disease 19 (COVID-19). In late December 2019, pneumonia cases of unknown origin were reported in Wuhan, China.
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